Caenorhabditis elegansGenAge entry for mdh-2 (Caenorhabditis elegans)

Gene information (ID: 428)

Symbol
mdh-2
Name
Malate DeHydrogenase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Mitochondrial malate dehydrogenase

Potential relevance to longevity and/or ageing

Observations
RNA interference decreased median lifespan by 10% in wild type animals and 16% in daf-2 mutants.
% change in avg or median lifespan
Median lifespan is 10% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as MDH1
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Mdh2
    • A homolog of this gene for Saccharomyces cerevisiae is present as MDH1

    Homologs in other organisms

    Danio rerio
    mdh2
    Drosophila melanogaster
    Mdh2
    Homo sapiens
    MDH2
    Mus musculus
    Mdh2
    Rattus norvegicus
    Mdh2
    Saccharomyces cerevisiae
    MDH1
    Schizosaccharomyces pombe
    MDH1

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (175936)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar