Drosophila melanogasterGenAge entry for loco (Drosophila melanogaster)

Gene information (ID: 865)

Symbol
loco
Aliases
CG17229; CG5248; dLoco; Dmel\CG5248; Loco
Name
locomotion defects
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of both genomic and cDNA loco gene significantly shortened the lifespan and resulted in a reduced stress resistance and lower fat content.
% change in avg or median lifespan
Mean male lifespan is 20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Reduced expression of Loco, a RGS protein of Drosophila melanogaster, resulted in a longer lifespan for both hetero-deficient male and female flies, also exhibiting stronger resistance to three different stressors (starvation, oxidation, and heat) and higher manganese-containing superoxide dismutase (MnSOD) activity. In addition, this reduction in Loco expression increased fat content and diminished cAMP levels. Deletion analysis of the Loco demonstrated that its RGS domain is required for the regulation of longevity.
    % change in avg or median lifespan
    Mean lifespan is 17-20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Knockout
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      rgs12a
      Homo sapiens
      RGS12
      Mus musculus
      Rgs12
      Rattus norvegicus
      Rgs12

      External links

      FlyBase
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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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