Caenorhabditis elegansGenAge entry for lmn-1 (Caenorhabditis elegans)

Gene information (ID: 414)

Symbol
lmn-1
Name
nuclear LaMiN
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Components of the nuclear lamina

Potential relevance to longevity and/or ageing

Observations
Deletion resulted in a shortened lifespan.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNAi led to a 39% decrease in median lifespan in daf-2 background, 12% decrease in lifespan in daf-2/daf-16 double mutant background and 12% decrease in median lifespan in a wild-type background.
    % change in avg or median lifespan
    Median lifespan is 30% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Mus musculus is present as Lmna
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as LMNA
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as LMNA

      Homologs in other organisms

      Danio rerio
      lmnb1
      Drosophila melanogaster
      Lam
      Homo sapiens
      LMNA
      Mus musculus
      Lmna
      Rattus norvegicus
      Lmna

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (172687)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar