Caenorhabditis elegansGenAge entry for lin-40 (Caenorhabditis elegans)

Gene information (ID: 216)

Symbol
lin-40
Name
abnormal cell LINeage
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Histone deacetylation

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 18% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpressing egr-1 extends lifespan (17-25%) and confers resistance to multiple stresses, while decreasing egr-1 levels suppresses the long lifespan of insulin signaling and germline mutants.
    % change in avg or median lifespan
    Lifespan is 17-25% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      RNA interference decreased median lifespan by 24% in wild type animals, 38% in a daf-2 background and 24% in daf-2/daf-16 double mutants.
      % change in avg or median lifespan
      Median lifespan is 24% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        Homologs in other organisms

        Danio rerio
        mta2
        Drosophila melanogaster
        MTA1-like
        Homo sapiens
        MTA2
        Mus musculus
        Mta2
        Rattus norvegicus
        Mta3

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (178788)
        Homologues
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        UniProt
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        Internet
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