Caenorhabditis elegansGenAge entry for lin-2 (Caenorhabditis elegans)

Gene information (ID: 410)

Symbol
lin-2
Name
abnormal cell LINeage
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Encodes a protein belonging to the membrane associated guanylate kinase (MAGUK)

Potential relevance to longevity and/or ageing

Observations
RNA interference extends lifespan.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    lin-1 inhibits the growth of gld-1 tumors. Up to 30% reduction in mean lifespan in daf-2 and gld-1 double mutant background; no mean lifespan change in daf-2 mutants or wild-type background; no significant changes in the maximum lifespan in all backgrounds except daf-2 and gld-1 double mutant background (40% reduction).
    Lifespan Effect
    Not Recorded
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      uncharacterized_F1QG
      Drosophila melanogaster
      CASK
      Homo sapiens
      CASK
      Mus musculus
      Cask
      Rattus norvegicus
      Cask

      External links

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      Internet
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