Caenorhabditis elegansGenAge entry for let-765 (Caenorhabditis elegans)

Gene information (ID: 473)

Symbol
let-765
Name
LEThal
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Notch signalling pathway

Potential relevance to longevity and/or ageing

Observations
RNA interference decreased median lifespan by 27% in wild type animals, 38% in a daf-2 background and 22% in daf-2/daf-16 double mutants.
% change in avg or median lifespan
Median lifespan is 27% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:ch73-63e15.2
    Drosophila melanogaster
    sno
    Homo sapiens
    SBNO1
    Mus musculus
    Sbno2
    Rattus norvegicus
    Sbno1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (175934)
    Homologues
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    UniProt
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    Internet
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