Caenorhabditis elegansGenAge entry for let-23 (Caenorhabditis elegans)

Gene information (ID: 953)

Symbol
let-23
Name
LEThal
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Let-23 mutants (reduction-of-function) survive less robustly in middle adulthood than matched wild type controls (19% decrease of median lifespan, 8% decrease of maximum lifespan)
% change in max lifespan
Maximum lifespan is 8% higher.
% change in avg or median lifespan
Median lifespan is 19% higher.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Let-23 mutants (gain-of-function) survive more robustly in middle adulthood (29% increase of median lifespan, 9% increase of maximum lifespan.
    % change in max lifespan
    Maximum lifespan is 9% higher.
    % change in avg or median lifespan
    Median lifespan is 29% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Drosophila melanogaster
      Egfr

      External links

      WormBase
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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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