Caenorhabditis elegansGenAge entry for itr-1 (Caenorhabditis elegans)

Gene information (ID: 949)

Symbol
itr-1
Name
Inositol Triphosphate Receptor
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Increased ITR-1 activity extends median and maximum lifespan (53% increase of median lifespan, 29% increase of maximum lifespan), whereas reduced ITR-1 activity shortens culture survival (i.e., -11% increase of median lifespan, -31% increase of maximum lifespan)
% change in max lifespan
Maximum lifespan is 29% higher.
% change in avg or median lifespan
Median lifespan is 53% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression or mutations
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    itpr2
    Drosophila melanogaster
    Itp-r83A
    Homo sapiens
    ITPR3
    Mus musculus
    Itpr3
    Rattus norvegicus
    Itpr3

    External links

    WormBase
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    Entrez Gene
    View on Entrez Gene database (177546)
    Homologues
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    UniProt
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    Internet
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