Caenorhabditis elegansGenAge entry for hsp-6 (Caenorhabditis elegans)

Gene information (ID: 346)

Symbol
hsp-6
Name
Heat shock 70kDa protein 9B (mortalin-2)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Stress-induced chaperone

Potential relevance to longevity and/or ageing

Observations
Overexpression in transgenic worms extended lifespan by 43% for mean and 45% for maximum lifespan.
% change in max lifespan
Maximum lifespan is 45% higher.
% change in avg or median lifespan
Average lifespan is 43% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Knockdown of HSP-6 by RNAi in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1, leading to abnormal mitochondrial morphology and lower ATP level. As a result, RNAi-treated worms had lower motility, defects in oogenesis, earlier accumulation of autofluorescent material and a shorter lifespan (15% reduction).
    % change in avg or median lifespan
    Lifespan is 15% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as HSPA9

      Homologs in other organisms

      Danio rerio
      hspa9
      Drosophila melanogaster
      Hsc70-5
      Homo sapiens
      HSPA9
      Mus musculus
      Hspa9
      Rattus norvegicus
      Hspa9
      Saccharomyces cerevisiae
      ECM10
      Schizosaccharomyces pombe
      ssp1

      External links

      WormBase
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (178873)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar