Caenorhabditis elegansGenAge entry for hsf-1 (Caenorhabditis elegans)

Gene information (ID: 341)

Symbol
hsf-1
Name
Heat shock transcription factor 1
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Transcription factor that is activated upon heat shock

Potential relevance to longevity and/or ageing

Observations
Transgenic mutants overexpressing HSF-1 live longer (median lifespan ~50% higher) and are more thermotolerant.
% change in avg or median lifespan
Median lifespan is approximately 50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    RNA interference suppressed normal dauer formation and life-extension due to insulin-like signalling.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      RNAi resulted in a 74% decrease in median lifespan in daf-2 background and a 45% decrease in lifespan in daf-2/daf-16 double mutant background.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as HSF1
        GenDR gene manipulations
        • This gene is present as hsf-1

        Homologs in other organisms

        Homo sapiens
        HSF1

        External links

        WormBase
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (173078)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar