Drosophila melanogasterGenAge entry for hop (Drosophila melanogaster)

Gene information (ID: 1818)

Symbol
hop
Aliases
4; CG1594; d-jak; Dm; JAK; Dmel\CG1594; DmHD-160; HD-160;
Name
hopscotch
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Flies heterozygous for the gain-of-function hopTum-l mutation exhibited shortened lifespans compared with wild-type control flies.
% change in max lifespan
Maximum lifespan is 10% lower.
% change in avg or median lifespan
Average lifespan is 30% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Flies heterozygous for a loss-of-function hop allele, hop3, had longer lifespans.
    % change in max lifespan
    Maximum lifespan is 20% higher.
    % change in avg or median lifespan
    Average lifespan is 17% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      CellAge
      • A homolog of this gene for Homo sapiens is present as TYK2

      Homologs in other organisms

      Danio rerio
      tyk2
      Homo sapiens
      TYK2
      Mus musculus
      Tyk2
      Rattus norvegicus
      Tyk2

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (32080)
      Homologues
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      UniProt
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      Internet
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