Caenorhabditis elegansGenAge entry for hif-1 (Caenorhabditis elegans)

Gene information (ID: 1937)

Symbol
hif-1
Name
HIF (Hypoxia Inducible Factor) homologa
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic overexpression of HIF-1 extends lifespan by 12-34% depending on the level of over-expression.
% change in avg or median lifespan
Mean lifespan is up to 34% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Deletion of HIF-1 (ia04) extends mean lifespan by 24%. Maximum lifespan is also extended.
    % change in avg or median lifespan
    Mean lifespan is 24% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Deletion of HIF-1 through a null-allele mutation (ia4) is not sufficient to significantly influence lifespan
      Lifespan Effect
      Not Recorded
      Genetic Manipulation
      Mutation
      Primary reference

        In other databases

        GenDR gene manipulations
        • This gene is present as hif-1

        Homologs in other organisms

        Danio rerio
        hif1al2
        Drosophila melanogaster
        Clk
        Mus musculus
        Hif3a
        Rattus norvegicus
        Hif3a

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (180359)
        Homologues
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        UniProt
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        Internet
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