Caenorhabditis elegansGenAge entry for hel-1 (Caenorhabditis elegans)

Gene information (ID: 2094)

Symbol
hel-1
Name
Spliceosome RNA helicase DDX39B homolog
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Hel-1 downregulation resulted in a 9.3% decrease in lifespan compared to wild type worms. This effect was even more pronounced in daf-2 mutants which showed a 26.9% decrease in lifespan. The results suggested that hel-1 promotes longevity by activating DAF-16/FOXO signalling.
% change in avg or median lifespan
Mean lifespan is 9% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    ddx39b
    Drosophila melanogaster
    Hel25E
    Homo sapiens
    DDX39B
    Mus musculus
    Ddx39b
    Rattus norvegicus
    Ddx39b
    Saccharomyces cerevisiae
    SUB2
    Schizosaccharomyces pombe
    uap56

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (174333)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar