Caenorhabditis elegansGenAge entry for gpa-11 (Caenorhabditis elegans)

Gene information (ID: 311)

Symbol
gpa-11
Name
G Protein, Alpha subunit
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
G Protein, Alpha subunit

Potential relevance to longevity and/or ageing

Observations
Increase in mean lifespan by up to 25% when gpa-11 is overexpressed and a slight (5%) but non-significant decrease in lifespan in knockouts. Lifespan extension was dependent on daf-16. Loss-of-function of odr-3 and extra copies of gpa-11 synergistically extended lifespan. Extra copies of gpa-11 shortened the lifespan of daf-2 mutants. Loss-of-function of gpa-11 in daf-2 mutants further extended lifespan.
% change in avg or median lifespan
Average lifespan is up to 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (173759)
    Homologues
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    UniProt
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    Internet
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