Caenorhabditis elegansGenAge entry for gpa-1 (Caenorhabditis elegans)

Gene information (ID: 309)

Symbol
gpa-1
Name
G Protein, Alpha subunit
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
G Protein, Alpha subunit

Potential relevance to longevity and/or ageing

Observations
Up to 10% maximum lifespan extension in gpa-1 knockouts. Loss-of-function of gpa-1 did not extend the lifespan of daf-2 mutants.
% change in max lifespan
Maximum lifespan is 10% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference
    Observations
    A 10% decrease in maximum lifespan when gpa-1 is overexpressed.
    % change in max lifespan
    Maximum lifespan is 10% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Overexpression
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Schizosaccharomyces pombe
      gpa1

      External links

      WormBase
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      Entrez Gene
      View on Entrez Gene database (179546)
      Homologues
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      UniProt
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      Internet
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