- Symbol
- frh-1
- Name
- FRataxin (involved in human Friedrich's ataxia) Homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Regulation of mitochondrial iron transport and respiration
- Observations
- While complete knock-out of FRH-1 results in arrested development or short lifespan, partial deficiency (without completely abolishing its expression) extends worm lifespan in a p53 dependent manner. It was however observed that a substantial frataxin suppression (more than 50% compared to wild-type) is required to extend C. elegans lifespan, while lower suppression levels displaying unsignificantly different longevity phenotypes.
- % change in max lifespan
- Maximum lifespan is aproximately 18% higher.
- % change in avg or median lifespan
- Median lifespan is aproximately 25% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Inactivation by RNA interference resulted in small body size, reduced fertility, altered responses to oxidative stress and life-extension.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Upon RNAi lifespan is significantly reduced, and worms have increased sensitivity to oxidative stress.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Fxn
- A homolog of this gene for Saccharomyces cerevisiae is present as YFH1
- CellAge
- A homolog of this gene for Homo sapiens is present as FXN
- Danio rerio
- fxn
- Homo sapiens
- FXN
- Mus musculus
- Fxn
- Rattus norvegicus
- Fxn
- Saccharomyces cerevisiae
- YFH1
- Schizosaccharomyces pombe
- SPCC1183.03c
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (174002)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for frh-1 (Caenorhabditis elegans)