Drosophila melanogasterGenAge entry for fh (Drosophila melanogaster)

Gene information (ID: 848)

Symbol
fh
Aliases
BcDNA:AT09528; CG8971; dfh; Dfh; DFH; Dmel\CG8971; X25
Name
frataxin homolog
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of Drosophila frataxin in the mitochondria of female transgenic animals increases antioxidant capability, resistance to oxidative stress insults, and longevity.
% change in max lifespan
Median lifespan is 35% higher; Maximum lifespan is 28% higher.
% change in avg or median lifespan
Median lifespan is 35% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as frh-1
    • A homolog of this gene for Mus musculus is present as Fxn
    • A homolog of this gene for Saccharomyces cerevisiae is present as YFH1

    Homologs in other organisms

    Caenorhabditis elegans
    frh-1
    Danio rerio
    fxn
    Homo sapiens
    FXN
    Mus musculus
    Fxn
    Rattus norvegicus
    Fxn
    Saccharomyces cerevisiae
    YFH1
    Schizosaccharomyces pombe
    SPCC1183.03c

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (31845)
    Homologues
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    UniProt
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    Internet
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