Caenorhabditis elegansGenAge entry for elc-1 (Caenorhabditis elegans)

Gene information (ID: 2097)

Symbol
elc-1
Name
ELongin C
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Downregulation of elc-1 increased lifespan by upregulating pro-longevity HIF-1. Downregulation of elc-1 also delayed paralysis in a worm model of Huntington's disease.
% change in avg or median lifespan
Mean lifespan is 12% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    tceb1a
    Drosophila melanogaster
    Elongin-C
    Homo sapiens
    TCEB1
    Mus musculus
    Tceb1
    Rattus norvegicus
    Tceb1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (190775)
    Homologues
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    UniProt
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    Internet
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