Caenorhabditis elegansGenAge entry for egl-30 (Caenorhabditis elegans)

Gene information (ID: 919)

Symbol
egl-30
Name
EGg Laying defective
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Egl-30 mutants (reduction-of-function) showed a 31% median lifespan extension (in the daf-16 background) and a 38% median lifespan extension (compared to wild type). Conversely, egl-30 (gain-of-function) constitutively active Gaq mutants were short-lived.
% change in avg or median lifespan
Median lifespan is 38% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    15% mean lifespan extension
    % change in avg or median lifespan
    Average lifespan is 15% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      gnaq
      Drosophila melanogaster
      Galpha49B
      Homo sapiens
      GNA11
      Mus musculus
      Gna11
      Rattus norvegicus
      Gna14

      External links

      WormBase
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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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