Caenorhabditis elegansGenAge entry for egl-27 (Caenorhabditis elegans)

Gene information (ID: 1790)

Symbol
egl-27
Name
Protein EGL-27
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of egl-27 extends the lifespan of wild-type animals. egl-27 is also required for longevity extension effects of impaired insulin/IGF-1 like signaling, as reduced egl-27 activity fully suppresses the longevity of daf-2 worms.
% change in max lifespan
Maximum lifespan is up to 10% higher.
% change in avg or median lifespan
Average lifespan is up to 17.9% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    rereb
    Drosophila melanogaster
    Gug
    Homo sapiens
    ATN1
    Mus musculus
    Atn1
    Rattus norvegicus
    Atn1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (174121)
    Homologues
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    UniProt
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    Internet
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