Drosophila melanogasterGenAge entry for dm (Drosophila melanogaster)

Gene information (ID: 1955)

Symbol
dm
Name
diminutive
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of dm (ortholog of the mammalian Myc) during larval development increases the frequency and the severity of somatic mutations, and shortens median lifespan by 42-47%. Maximum lifespan is 30-40% shorter. Contrastly, dm haploinsufficiency lowers the frequency of somatic mutations and extends lifespan by about 14%.
% change in max lifespan
Maximum lifespan is up to 40% lower.
% change in avg or median lifespan
Median lifespan is up to 47% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (31310)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar