Caenorhabditis elegansGenAge entry for ddl-2 (Caenorhabditis elegans)

Gene information (ID: 173)

Symbol
ddl-2
Name
Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference results in lifespan extension.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Inhibition of DDL-1/2 increases longevity and thermotolerance in an hsf-1-dependent manner. RNAi extends lifespan by 12%-24%.
    % change in avg or median lifespan
    Lifespan is 12-24% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      Wash1
      Drosophila melanogaster
      wash
      Homo sapiens
      WASH6P
      Mus musculus
      Wash1
      Rattus norvegicus
      Wash

      External links

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      Entrez Gene
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      Homologues
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      UniProt
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      Internet
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