Caenorhabditis elegansGenAge entry for daf-7 (Caenorhabditis elegans)

Gene information (ID: 169)

Symbol
daf-7
Name
abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Encodes a member of the TGF-beta superfamily that affects dauer larvae

Potential relevance to longevity and/or ageing

Observations
Mutations cause up to 50% mean and maximum life-extension. This effect is dependent upon daf-3 and on daf-16 but independent of daf-2. RNA interference increased mean lifespan by 30% and maximum lifespan by 10%.
% change in max lifespan
Maximum lifespan is up to 50% higher.
% change in avg or median lifespan
Average lifespan is up to 50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as daw
    • A homolog of this gene for Mus musculus is present as Mstn
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as MSTN

    Homologs in other organisms

    Danio rerio
    gdf11
    Drosophila melanogaster
    daw
    Homo sapiens
    MSTN
    Mus musculus
    Mstn
    Rattus norvegicus
    Inhbb

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (175237)
    Homologues
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    UniProt
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    Internet
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