Caenorhabditis elegansGenAge entry for daf-18 (Caenorhabditis elegans)

Gene information (ID: 161)

Symbol
daf-18
Name
Abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Lipid phosphatase

Potential relevance to longevity and/or ageing

Observations
Knockdown of daf-18 decreased lifespan.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    The increased lifespan of daf-2 mutants is partially suppressed in a daf- 2; daf-18 double mutant.
    Lifespan Effect
    Not Recorded
    Genetic Manipulation
    Mutations
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Required for complete dauer formation. Overexpression increases adult lifespan in individual tissues.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        Overexpression resulted in a 30% mean lifespan extension.
        % change in avg or median lifespan
        Average lifespan is 30% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Overexpression
        Longevity Category
        Pro-Longevity
        Primary reference

          Homologs in other organisms

          No homologs found

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (176869)
          Homologues
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          UniProt
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          Internet
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