Caenorhabditis elegansGenAge entry for daf-16 (Caenorhabditis elegans)

Gene information (ID: 160)

Symbol
daf-16
Name
Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Forkhead family transcription factor

Potential relevance to longevity and/or ageing

Observations
The increased lifespan of daf-2 and daf-23 mutants is suppressed completely by a daf-16 mutation.
Lifespan Effect
Not Recorded
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mutations in daf-16 suppress the life-extension caused by several mutations, including daf-2.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutation
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      70% decrease in median lifespan in daf-2 background and 45% decrease in lifespan in wild-type background.
      % change in avg or median lifespan
      Average lifespan is 45% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenDR gene manipulations
        • This gene is present as daf-16

        Homologs in other organisms

        Danio rerio
        si:dkey-11f5.5
        Mus musculus
        Foxo6

        External links

        WormBase
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (172981)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar