Caenorhabditis elegansGenAge entry for daf-12 (Caenorhabditis elegans)

Gene information (ID: 157)

Symbol
daf-12
Name
Abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
A member of the steroid hormone receptor superfamily

Potential relevance to longevity and/or ageing

Observations
Mutations in daf-2 and daf-12, but not mutations in daf-12 alone, nearly quadruple lifespan.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    daf-12(rh61rh411) is a class 3 daf-12 allele which is daf-d and results in shortened lifespan. This allele represents a putative null allele as it has two nonsense mutations affecting both the DNA binding domain (DBD) and ligand-binding domain (LBD). daf-12(rh273) is a class 6 daf-12 allele which is daf-c and results in lengthened lifespan. This allele has a R564H mutation altering a residue that in the thyroid hormone receptor makes direct contact with ligand and is believed to result in hormone insensitivity.daf-12(rh273) was much longer lived than the daf-12(rh61rh411) and showed a modest but significant increase in lifespan compared with wild-type N2 worms. The daf-12(rh273) allele results in a 38% increase in lifespan compared with daf-12(rh61rh411) and a 10% increase in lifespan compared with wild-type worms
    Lifespan Effect
    Not Recorded
    Genetic Manipulation
    Mutations
    Primary reference

      Homologs in other organisms

      Danio rerio
      thrab
      Drosophila melanogaster
      Hr96
      Homo sapiens
      THRB
      Rattus norvegicus
      Thra

      External links

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      Entrez Gene
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      Internet
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