Caenorhabditis elegansGenAge entry for ctbp-1 (Caenorhabditis elegans)

Gene information (ID: 1873)

Symbol
ctbp-1
Name
C-terminal-binding protein 1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
The C. elegans ctbp-1 mutants (ok498), lacking the NAD(H)-binding domain and most of the dehydrogenase catalytic domain, display an increase in mean adult life span (~20%) and maximal life span (~10–20%). Depletion of ctbp-1 by RNA interference results in similar lifespan extension effects, while reintroduction of the ctbp-1 gene rescues the lifespan phenotype. Most probably, CTBP-1 modulates aging through the insulin/IGF-1 signaling pathway and its effect is dependent on existence of DAF-16.
% change in max lifespan
Maximum lifespan is up to 20% higher.
% change in avg or median lifespan
Mean lifespan is about 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Knockdown mutations (eg613 and tm5512) in CTBP-1 result in a lifespan expansion of up to 5-10% and 5-25%, respectively. Constrastly to previous observations however (Chen et al., 2009), no change in lifespan was observed for the ok498 mutation (which might be due to using independently outcrossed strains derived from RB733 ctbp-1 ok498).
    % change in avg or median lifespan
    Median lifespan is up to 20% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      ctbp1
      Drosophila melanogaster
      CtBP

      External links

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      Entrez Gene
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