Caenorhabditis elegansGenAge entry for clk-1 (Caenorhabditis elegans)

Gene information (ID: 130)

Symbol
clk-1
Name
Coenzyme Q7 homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Ubiquinone (coenzyme Q, CoQ) biosynthesis

Potential relevance to longevity and/or ageing

Observations
Mutations slow down development and extend lifespan.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Primary reference
    Observations
    Overexpression of CLK-1 activity in wild-type worms can increase mitochondrial activity, accelerate behavioral rates during aging and shorten lifespan.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Overexpression
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNAi resulted in a lifespan extension by 40%.
      % change in avg or median lifespan
      Lifespan is 40% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Clk-1 mutants display lifespan extension compared to wild-type.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Mutation
        Longevity Category
        Anti-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Mus musculus is present as Coq7
          • A homolog of this gene for Saccharomyces cerevisiae is present as CAT5
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as COQ7
          GenDR gene manipulations
          • This gene is present as clk-1
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as COQ7

          Homologs in other organisms

          Danio rerio
          zgc:158731
          Drosophila melanogaster
          COQ7
          Homo sapiens
          COQ7
          Mus musculus
          Coq7
          Rattus norvegicus
          Coq7
          Saccharomyces cerevisiae
          CAT5
          Schizosaccharomyces pombe
          coq7

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (175729)
          Homologues
          Search HomoloGene
          UniProt
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          Internet
          Search Google or Search Google Scholar