Caenorhabditis elegansGenAge entry for ceh-23 (Caenorhabditis elegans)

Gene information (ID: 1819)

Symbol
ceh-23
Name
Protein CEH-23
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Worms transformed with 10 ng/ul of ceh-23 (red curve) rwEx16[ceh-23+mec-7::rfp] showed an increased lifespan (p<0.001, log-rank test) when compared to rwEx18[mec-7::rfp] control worms (black curve). By contrast, worms transformed with 1 ng/ul of ceh-23 (green curve) rwEx17[ceh-23+mec-7::rfp] showed only marginal lifespan increased (p = 0.036, log rank test) when compared to rwEx18[Pmec-7::rfp] control worms (black curve).
% change in max lifespan
Maximum lifespan is 30% higher.
% change in avg or median lifespan
Average lifespan is 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
    % change in avg or median lifespan
    Average lifespan is 12% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Drosophila melanogaster
      exex

      External links

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