Caenorhabditis elegansGenAge entry for ceh-20 (Caenorhabditis elegans)

Gene information (ID: 1820)

Symbol
ceh-20
Name
Protein CEH-20
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
% change in avg or median lifespan
Average lifespan is 12% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    pbx3a
    Drosophila melanogaster
    exd
    Homo sapiens
    PBX4
    Mus musculus
    Pbx4
    Rattus norvegicus
    Pbx4

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (3565545)
    Homologues
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    UniProt
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    Internet
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