Caenorhabditis elegansGenAge entry for bmk-1 (Caenorhabditis elegans)

Gene information (ID: 2100)

Symbol
bmk-1
Name
Kinesin-like protein
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of bmk-1 in worms resulted in a 25% increase in lifespan and enhanced heat shock resistance. Downregulation of bmk-1 using RNAi resulted in a 32% decrease in lifespan. Hsp-16 was upregulated in response to bmk-1 overexpression, suggesting bmk-1 may protect cells from stress and inhibit apoptosis.
% change in avg or median lifespan
Median lifespan is 25% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Drosophila melanogaster
    Klp61F
    Homo sapiens
    KIF11
    Mus musculus
    Kif11
    Rattus norvegicus
    Kif11
    Saccharomyces cerevisiae
    KIP1
    Schizosaccharomyces pombe
    cut7

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (179948)
    Homologues
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    UniProt
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    Internet
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