Caenorhabditis elegansGenAge entry for bec-1 (Caenorhabditis elegans)

Gene information (ID: 44)

Symbol
bec-1
Name
BEClin (human autophagy) homolog
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Involved in autophagy

Potential relevance to longevity and/or ageing

Observations
Required for normal dauer morphogenesis and lifespan extension. RNA interference results in a shortened lifespan.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Shortened mean lifespan in eat-2 mutant background (24%) but not in wild-type.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    RNA interference
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      RNAi resulted in a 10-40% reduction in mean lifespan.
      % change in avg or median lifespan
      Average lifespan is 10-40% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        16% lifespan reduction (compared to wild type) and 25% lifespan reduction (in a daf-2 mutant) for RNAi from beginning of life. For post developmental RNAi maximum lifespan was extended by 10-15% both in wild-type and daf2 mutants.
        % change in avg or median lifespan
        Lifespan is up to 16% higher.
        Lifespan Effect
        Decrease
        Genetic Manipulation
        RNA interference
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenDR gene manipulations
          • This gene is present as bec-1

          Homologs in other organisms

          Danio rerio
          becn1
          Drosophila melanogaster
          Atg6
          Homo sapiens
          BECN1P1
          Mus musculus
          Becn1
          Rattus norvegicus
          RGD1563293
          Schizosaccharomyces pombe
          atg6

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (177345)
          Homologues
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          UniProt
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          Internet
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