Caenorhabditis elegansGenAge entry for atg-7 (Caenorhabditis elegans)

Gene information (ID: 23)

Symbol
atg-7
Name
AuTophaGy (yeast Atg homolog)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Autophagic vesicle expansion

Potential relevance to longevity and/or ageing

Observations
RNA interference shortened mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild type animals.
Lifespan Effect
Not Recorded
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Post developmental RNAi resulted in a 10-15% maxumal lifespan extension compared to wild type. No lifespan extension by RNAi from the beginning of life.
    % change in max lifespan
    Maximum lifespan is 10-15% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Drosophila melanogaster is present as Atg7
      • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
      GenDR gene manipulations
      • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
      • This gene is present as atg-7

      Homologs in other organisms

      Danio rerio
      uncharacterized_E7F5
      Drosophila melanogaster
      Atg7
      Homo sapiens
      ATG7
      Mus musculus
      Atg7
      Rattus norvegicus
      Atg7
      Saccharomyces cerevisiae
      ATG7
      Schizosaccharomyces pombe
      atg7

      External links

      WormBase
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (178005)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar