Caenorhabditis elegansGenAge entry for apl-1 (Caenorhabditis elegans)

Gene information (ID: 2093)

Symbol
apl-1
Name
Beta-amyloid-like protein
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Apl-1 expression was induced in adult worms via heat shock. A single induction in day one adults mildly increased lifespan (5%) whereas regular apl-1 expression robustly increased lifespan (12-30%). Tissue specific expression had differing effects, neuron specific expression resulted in a decrease in lifespan whereas hypodermis specific expression resulted in lifespan extension.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as APLP1

    Homologs in other organisms

    Danio rerio
    aplp1
    Drosophila melanogaster
    Appl
    Homo sapiens
    APLP1
    Mus musculus
    Aplp1
    Rattus norvegicus
    Aplp1

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (180783)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar