Caenorhabditis elegansGenAge entry for apl-1 (Caenorhabditis elegans)

Gene information (ID: 2093)

Symbol
apl-1
Name
Beta-amyloid-like protein
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Apl-1 expression was induced in adult worms via heat shock. A single induction in day one adults mildly increased lifespan (5%) whereas regular apl-1 expression robustly increased lifespan (12-30%). Tissue specific expression had differing effects, neuron specific expression resulted in a decrease in lifespan whereas hypodermis specific expression resulted in lifespan extension.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    appa
    Drosophila melanogaster
    Appl
    Homo sapiens
    APLP2
    Mus musculus
    Aplp1
    Rattus norvegicus
    Aplp2

    External links

    WormBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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