Drosophila melanogasterGenAge entry for alpha-Man-I (Drosophila melanogaster)

Gene information (ID: 833)

Symbol
alpha-Man-I
Aliases
alpha-Man-l; CG17809; CG18799; CG32682; CG32684; CG4227
Name
Alpha Mannosidase I
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutant flies showed enhanced resistance to paraquat and starvation and a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant showed, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males . The increase in maximum lifespan was 15%. RNAi knock-downs resulted in a 39% increase in mean lifespan.
% change in max lifespan
Maximum lifespan is 15% higher.
% change in avg or median lifespan
Average male lifespan is 38% higher; Average female lifespan is 22% higher; Average lifespan is 39% higher for RNAi knock-downs.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference, Mutations
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as D2030.1

    Homologs in other organisms

    Caenorhabditis elegans
    mans-1
    Danio rerio
    man1a1
    Homo sapiens
    MAN1A1
    Mus musculus
    Man1a1
    Rattus norvegicus
    Man1c1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (31957)
    Homologues
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    UniProt
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    Internet
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