Caenorhabditis elegansGenAge entry for aco-2 (Caenorhabditis elegans)

Gene information (ID: 5)

Symbol
aco-2
Name
ACOnitase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Required for embryonic viability, fertility, locomotion, and vulval morphogenesis

Potential relevance to longevity and/or ageing

Observations
RNA interference of aco-2 results in an increased lifespan.
% change in avg or median lifespan
Mean lifespan is 20.5% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA interference leads to lifespan extension.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      30% mean lifespan extension in daf2 background; no lifespan measurement in wt background
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference

        Homologs in other organisms

        Danio rerio
        aco2
        Drosophila melanogaster
        CG4706
        Homo sapiens
        ACO2
        Mus musculus
        Aco2
        Rattus norvegicus
        Aco2
        Saccharomyces cerevisiae
        ACO1
        Schizosaccharomyces pombe
        SPAC24C9.06c

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (176121)
        Homologues
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        UniProt
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        Internet
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