- Symbol
- acn-1
- Name
- Inactive angiotensin-converting enzyme-related protein
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- When acn-1, a worm homologue of ACE, was downregulated mean lifespan was increased 21% and maximum lifespan increased 18%. Similar results were shown when acn-1 was downregulated from adulthood. In addition, lifespan was increased at higher temperatures, age-related degenerative changes were delayed and stress resistance was increased.
- % change in max lifespan
- Maximum lifespan is 18% higher.
- % change in avg or median lifespan
- Mean lifespan is 21% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- LongevityMap
- A homolog of this gene for Homo sapiens is present as ACE
- Danio rerio
- TMEM27
- Danio rerio
- ace2
- Danio rerio
- ace
- Drosophila melanogaster
- Ance-4
- Drosophila melanogaster
- Ance-5
- Drosophila melanogaster
- Ance-3
- Drosophila melanogaster
- Acer
- Drosophila melanogaster
- Ance-2
- Drosophila melanogaster
- Ance
- Homo sapiens
- ACE2
- Homo sapiens
- TMEM27
- Homo sapiens
- ACE
- Homo sapiens
- 0
- Mus musculus
- Ace3
- Mus musculus
- Tmem27
- Mus musculus
- Ace
- Mus musculus
- Ace2
- Rattus norvegicus
- Ace3
- Rattus norvegicus
- Ace2
- Rattus norvegicus
- Tmem27
- Rattus norvegicus
- Ace
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180780)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for acn-1 (Caenorhabditis elegans)