Caenorhabditis elegansGenAge entry for aak-2 (Caenorhabditis elegans)

Gene information (ID: 1)

Symbol
aak-2
Name
AMP-Activated Kinase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Energy sensor and signal transduction

Potential relevance to longevity and/or ageing

Observations
Transgenic animals with a higher aak-2 gene dose live on average 13% longer than controls.
% change in avg or median lifespan
Mean lifespan is 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
    Lifespan Effect
    Increases
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
      Lifespan Effect
      Increases
      Genetic Manipulation
      Overexpression
      Primary reference
        Observations
        Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
        Lifespan Effect
        Increases
        Genetic Manipulation
        Overexpression
        Longevity Category
        Pro-Longevity
        Primary reference
          Observations
          Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
          Lifespan Effect
          Increases
          Genetic Manipulation
          Overexpression
          Longevity Category
          Pro-Longevity
          Primary reference
            Observations
            Could be a sensor that couples energy levels and insulin-like signals to lifespan. Knockout mutants have a 12% shorter lifespan.
            % change in avg or median lifespan
            Lifespan is 12% lower.
            Lifespan Effect
            Decrease
            Genetic Manipulation
            Knockout
            Longevity Category
            Pro-Longevity
            Primary reference
              Observations
              37% decrease in median lifespna in daf-2 background and 54% decrease in lifespan in a wild-type background
              % change in avg or median lifespan
              Median lifespan is 54% lower.
              Lifespan Effect
              Decrease
              Genetic Manipulation
              RNA interference
              Longevity Category
              Pro-Longevity
              Primary reference

                In other databases

                GenAge model organism genes
                • A homolog of this gene for Drosophila melanogaster is present as SNF1A
                GenDR gene manipulations
                • This gene is present as aak-2

                Homologs in other organisms

                Danio rerio
                prkaa2
                Drosophila melanogaster
                SNF1A
                Homo sapiens
                NIM1
                Mus musculus
                Prkaa1
                Rattus norvegicus
                Prkaa1

                External links

                WormBase
                Search
                Ensembl
                Search
                Entrez Gene
                View on Entrez Gene database (181727)
                Homologues
                Search HomoloGene
                UniProt
                Search
                Internet
                Search Google or Search Google Scholar