Caenorhabditis elegansGenAge entry for aak-2 (Caenorhabditis elegans)

Gene information (ID: 1)

Symbol
aak-2
Name
AMP-Activated Kinase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Energy sensor and signal transduction

Potential relevance to longevity and/or ageing

Observations
Transgenic animals with a higher aak-2 gene dose live on average 13% longer than controls.
% change in avg or median lifespan
Mean lifespan is 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Constitutively activated aak-2 increased worm lifespan however induced detrimental pleiotropic side effects including small body size and a reduced reproductive capacity. Worms also showed increased heat resistance, demonstrating a 125% increase in median lifespan at 33 degrees Celsius compared to wild type animals. The lifespan extension effect was dependent on crtc-1 at low temperatures but not high ones.
    Lifespan Effect
    Increases
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Could be a sensor that couples energy levels and insulin-like signals to lifespan. Knockout mutants have a 12% shorter lifespan.
      % change in avg or median lifespan
      Lifespan is 12% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Knockout
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        37% decrease in median lifespna in daf-2 background and 54% decrease in lifespan in a wild-type background
        % change in avg or median lifespan
        Median lifespan is 54% lower.
        Lifespan Effect
        Decrease
        Genetic Manipulation
        RNA interference
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Drosophila melanogaster is present as SNF1A
          GenDR gene manipulations
          • This gene is present as aak-2

          Homologs in other organisms

          Danio rerio
          prkaa2
          Drosophila melanogaster
          SNF1A
          Homo sapiens
          NIM1
          Mus musculus
          Prkaa1
          Rattus norvegicus
          Prkaa1

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (181727)
          Homologues
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          UniProt
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          Internet
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