Caenorhabditis elegansGenAge entry for aak-2 (Caenorhabditis elegans)

Gene information (ID: 1)

Symbol
aak-2
Name
AMP-Activated Kinase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Energy sensor and signal transduction

Potential relevance to longevity and/or ageing

Observations
Transgenic animals with a higher aak-2 gene dose live on average 13% longer than controls.
% change in avg or median lifespan
Mean lifespan is 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Could be a sensor that couples energy levels and insulin-like signals to lifespan. Knockout mutants have a 12% shorter lifespan.
    % change in avg or median lifespan
    Lifespan is 12% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Knockout
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      37% decrease in median lifespna in daf-2 background and 54% decrease in lifespan in a wild-type background
      % change in avg or median lifespan
      Median lifespan is 54% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Drosophila melanogaster is present as SNF1A
        GenDR gene manipulations
        • This gene is present as aak-2

        Homologs in other organisms

        Drosophila melanogaster
        SNF1A
        Danio rerio
        prkaa2
        Homo sapiens
        NIM1
        Mus musculus
        Prkaa1
        Rattus norvegicus
        Prkaa1

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (181727)
        Homologues
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        UniProt
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        Internet
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