Drosophila melanogasterGenAge entry for Zw (Drosophila melanogaster)

Gene information (ID: 883)

Symbol
Zw
Aliases
CG12529; Dmel\CG12529; G-6-PD; G-6-pdh; G-6pd; G-6PD; G6
Name
Zwischenferment
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
The mean lifespans of G6PD overexpressor flies were extended, in comparison with driver and responder controls, as follows: armadillo-GAL4 (up to 38%), Tubulin-GAL4 (up to 29%), C23-GAL4 (up to 27%), da-GAL4 (up to 24%), D42-GAL4 (up to 18%), and Appl-GAL4 (up to 16%). Maximum lifespan was also increased. The G6PD enzymatic activity was increased, as were the levels of NADPH, NADH, and the GSH/GSSG ratio.
% change in avg or median lifespan
Average lifespan is up to 38% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as ZWF1
    • A homolog of this gene for Mus musculus is present as G6PD
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as G6PD
    CellAge
    • A homolog of this gene for Homo sapiens is present as G6PD

    Homologs in other organisms

    Caenorhabditis elegans
    gspd-1
    Danio rerio
    g6pd
    Homo sapiens
    G6PD
    Mus musculus
    G6pd2
    Rattus norvegicus
    G6pdx
    Saccharomyces cerevisiae
    ZWF1
    Schizosaccharomyces pombe
    zwf1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (32974)
    Homologues
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    UniProt
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    Internet
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