Mus musculusGenAge entry for Xrcc6 (Mus musculus)

Gene information (ID: 736)

Symbol
Xrcc6
Aliases
Ku70; 70kDa; G22p1
Name
X-ray repair complementing defective repair in Chinese hamster cells 6
Organism
Mus musculus (AnAge)
Known functions and activities
The double strand break-repair protein

Potential relevance to longevity and/or ageing

Observations
XRCC5 and XRCC6 double knockout mice show decreased lifespan and signs of premature ageing without increase cancer incidence.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as cku-70
    • A homolog of this gene for Saccharomyces cerevisiae is present as YKU70
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as XRCC6
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as XRCC6

    Homologs in other organisms

    Caenorhabditis elegans
    cku-70
    Danio rerio
    uncharacterized_E7FG
    Drosophila melanogaster
    Irbp
    Homo sapiens
    XRCC6
    Rattus norvegicus
    Xrcc6
    Saccharomyces cerevisiae
    YKU70
    Schizosaccharomyces pombe
    pku70

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (14375)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar