Mus musculusGenAge entry for Xrcc5 (Mus musculus)

Gene information (ID: 735)

Symbol
Xrcc5
Aliases
Ku80; Ku86; AI314015
Name
X-ray repair complementing defective repair in Chinese hamster cells 5
Organism
Mus musculus (AnAge)
Known functions and activities
Double strand break-repair protein

Potential relevance to longevity and/or ageing

Observations
Deletion results in signs of premature ageing such as osteopenia, atrophic skin, hepatocellular degeneration, and age specific mortality.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Up to ~40% reduced lifespan.
    % change in avg or median lifespan
    Lifespan is about 40% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutations
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as XRCC5
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as XRCC5

      Homologs in other organisms

      Caenorhabditis elegans
      cku-80
      Danio rerio
      xrcc5
      Drosophila melanogaster
      Ku80
      Homo sapiens
      XRCC5
      Rattus norvegicus
      Xrcc5
      Schizosaccharomyces pombe
      pku80

      External links

      Mouse Genome Informatics
      Search
      Ensembl
      Search
      Entrez Gene
      View on Entrez Gene database (22596)
      Homologues
      Search HomoloGene
      UniProt
      Search
      Internet
      Search Google or Search Google Scholar