Drosophila melanogasterGenAge entry for Vinc (Drosophila melanogaster)

Gene information (ID: 2083)

Symbol
Vinc
Name
Vinculin
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Cardiac-restricted Vinc overexpression lead to a increased median lifespan of up to 150% in flies. The cortical cytoskeleton was reinforced, along with enhanced myofilament organisation. These results suggested the heart has molecular mechanisms to promote longevity.
% change in max lifespan
Maximum lifespan is 169% higher
% change in avg or median lifespan
Median lifespan is 150% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Caenorhabditis elegans
    deb-1
    Danio rerio
    vcl
    Homo sapiens
    VCL
    Mus musculus
    Vcl
    Rattus norvegicus
    Vcl

    External links

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    Internet
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