Saccharomyces cerevisiaeGenAge entry for UMP1 (Saccharomyces cerevisiae)

Gene information (ID: 700)

Symbol
UMP1
Aliases
RNS2
Name
Ump1p
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Proteasome assembly protein

Potential relevance to longevity and/or ageing

Observations
Ump1 mutants exhibit reduced replicative lifespan.
% change in avg or median lifespan
Mean replicative lifespan is 32% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Necessary for fitness
Primary reference
    Observations
    Overexpression caused an enhanced preservation of proteasome-mediated protein degradation and enhanced viability during stationary-phase ageing.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      Danio rerio
      pomp
      Homo sapiens
      POMP
      Mus musculus
      Pomp
      Rattus norvegicus
      LOC100911238
      Schizosaccharomyces pombe
      ump1

      External links

      Saccharomyces Genome Database
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (852471)
      Homologues
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      UniProt
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      Internet
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