Drosophila melanogasterGenAge entry for UCP2 (Drosophila melanogaster)

Gene information (ID: 695)

Symbol
UCP2
Aliases
UCPH; BMIQ4; SLC25A8
Name
uncoupling protein 2 (mitochondrial, proton carrier)
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of human UCP2 in the fly nervous system extended lifespan by 10-30%. Ubiquitous overexpression was lethal.
% change in avg or median lifespan
Lifespan is 10-30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Ucp2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as UCP2
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as UCP2

    Homologs in other organisms

    Homo sapiens
    UCP2
    Homo sapiens
    UCP2
    Homo sapiens
    UCP2

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (7351)
    Homologues
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    UniProt
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    Internet
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