Mus musculusGenAge entry for Txn1 (Mus musculus)

Gene information (ID: 691)

Symbol
Txn1
Aliases
ADF; Txn; Trx1; AW550880
Name
Thioredoxin 1
Organism
Mus musculus (AnAge)
Known functions and activities
TXN plays a role in regulating cellular redox status and perhaps oxidative stress

Potential relevance to longevity and/or ageing

Observations
Overexpression in mice resulted in no overall effects on lifespan, although it could be beneficial in the earlier part of life.
Lifespan Effect
Noeffect
Longevity Category
Not Recorded
Primary reference
    Observations
    Overexpression in transgenic mice resulted in extended median and maximum (35%) lifespan.
    % change in max lifespan
    Maximum lifespan is approximately 35% higher.
    % change in avg or median lifespan
    Median lifespan is approximately 35% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Drosophila melanogaster is present as TrxT
      • A homolog of this gene for Saccharomyces cerevisiae is present as TRX1
      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as TXN
      CellAge
      • A homolog of this gene for Homo sapiens is present as TXN

      Homologs in other organisms

      Danio rerio
      txn
      Drosophila melanogaster
      TrxT
      Homo sapiens
      TXN
      Rattus norvegicus
      Txn
      Saccharomyces cerevisiae
      TRX1
      Schizosaccharomyces pombe
      trx1

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (22166)
      Homologues
      Search HomoloGene
      UniProt
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      Internet
      Search Google or Search Google Scholar