- Symbol
- Trp63
- Aliases
- Ket; P63; P73l; Tp63; P51/P63; AI462811; Trp53rp1
- Name
- Transformation related protein 63
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Proliferation, differentiation, and cell fate
- Observations
- Heterozygous mice have a shortened lifespan and display features of accelerated ageing.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Mice exhibited an accelerated aging phenotype in the skin characterized by striking wound healing defects, decreased skin thickness, decreased subcutaneous fat tissue, hair loss, and decreased cell proliferation. The accelerated skin aging was accompanied by a dramatic decrease in longevity of the mice.The DNp63a transgenic mice had a dramatically shortened median lifespan of seven months (n = 164), compared to the normal mouse lifespan of more than 24 months (n = 180)
- % change in avg or median lifespan
- Median lifespan si about 70% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression in skin
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as TP63
- CellAge
- A homolog of this gene for Homo sapiens is present as TP63
- Danio rerio
- tp63
- Homo sapiens
- TP63
- Rattus norvegicus
- Tp63
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (22061)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Trp63 (Mus musculus)