Mus musculusGenAge entry for Trp53bp1 (Mus musculus)

Gene information (ID: 830)

Symbol
Trp53bp1
Aliases
53BP1; m53BP1; Tp53bp1
Name
Transformation related protein 53 binding protein 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
An extended lifespan and near-wild-type longevity of 53BP1-/- mice in the BRCA1 mutation background was observed. This was also accompanied by a relative absence of various progeriod phenotypes.
Lifespan Effect
Increase
Genetic Manipulation
Deletion in the BRCA1 mutant background
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as TP53BP1

    Homologs in other organisms

    Caenorhabditis elegans
    hsr-9
    Danio rerio
    zgc:158452
    Homo sapiens
    TP53BP1
    Rattus norvegicus
    Tp53bp1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (27223)
    Homologues
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    UniProt
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    Internet
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