Mus musculusGenAge entry for Tpp2 (Mus musculus)

Gene information (ID: 829)

Symbol
Tpp2
Aliases
TPP-2; TppII
Name
Tripeptidyl peptidase II
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Young KO mice are viable and grossly indistinguishable from WT littermates. Over 1 year of age KO mice show elevated mortality associated with aged appearance, disheveled fur, large bald areas, reduced body mass, and loss of vigor. Mice also show symptoms characteristic of immunohematopoietic senescence, including accelerated thymic involution, lymphopenia, impaired proliferative T cell responses, extramedullary hematopoiesis, and inflammation.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as TPP2

    Homologs in other organisms

    Caenorhabditis elegans
    F21H12.6
    Danio rerio
    tpp2
    Drosophila melanogaster
    TppII
    Homo sapiens
    TPP2
    Rattus norvegicus
    Tpp2
    Schizosaccharomyces pombe
    tpp2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (22019)
    Homologues
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    UniProt
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    Internet
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