Mus musculusGenAge entry for Topors (Mus musculus)

Gene information (ID: 828)

Symbol
Topors
Aliases
LUN; TP53BPL; AW105885; p53BP3/LUN
Name
Topoisomerase I binding, arginine/serine-rich
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mice exhibited a significant reduction in mean and maximal lifespan for homozygote KO, slight reduction in mean and maximal lifespan for heterozygote KO compared to WT. Several mice showed some signs of premature aging, including kyphosis, and a high incidence of cancer (multiple forms of tumors).
% change in max lifespan
Maximum lifespan is 42% lower.
% change in avg or median lifespan
Median lifespan is 42% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:ch211-145b13.4
    Drosophila melanogaster
    Topors
    Homo sapiens
    TOPORS
    Rattus norvegicus
    Topors

    External links

    Mouse Genome Informatics
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    Entrez Gene
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    UniProt
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    Internet
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