Drosophila melanogasterGenAge entry for Top3alpha (Drosophila melanogaster)

Gene information (ID: 2108)

Symbol
Top3alpha
Name
Topoisomerase 3alpha
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutant M1L flies, which lack mitochondrial Top3alpha, show decreased median and maximum lifespan when compared to wild type flies. The flies demonstrated a premature ageing phenotype, had mobility defects, and exhibited elevated levels of mitochondrial degeneration.
% change in max lifespan
Maximum lifespan is 25% lower.
% change in avg or median lifespan
Median lifespan is 20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Caenorhabditis elegans
    top-3
    Danio rerio
    top3a
    Homo sapiens
    TOP3A
    Mus musculus
    Top3a
    Rattus norvegicus
    Top3a
    Saccharomyces cerevisiae
    TOP3
    Schizosaccharomyces pombe
    top3

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (35236)
    Homologues
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    UniProt
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    Internet
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